BYU Genomics and Bioinformatics Center

Summary

The Genomics and Bioinformatics Center (GBC) at Brigham Young University is a campus-wide resource dedicated to making advanced genomic research accessible, affordable, and efficient. By centralizing state-of-the-art sequencing technologies, robust computational pipelines, and expert consultation, the GBC enables researchers and students to generate, analyze, and interpret genomic data with confidence. Our mission is to provide high-quality sequencing and analysis services while also offering training at both the experimental and bioinformatic levels to prepare students with the skills needed for modern genomic research.

To request services, BYU staff and students can login or create an account. External users can email dnasc@byu.edu.

Services

Below are some of the services provided by the GBC. Please see policies and pricing for more details.

Genomic Services

• Custom PacBio HiFi sequencing on Revio using SPRQ chemistry, including DNA extraction, library prep and sequencing:
  
  • WGS
  • Iso-Seq
  • Kinnex
  • single cell Kinnex
  • Amplicon sequencing (amplicons <3Kbp)
  • Fiber Seq (Through collaboration)
• Custom DNA Sequencing on 3730xl with dideoxy sequencing chemistry

• DNA/RNA Fragment Analysis
  
  • Femto Pulse
  • Fragment Analyzer

• Single Cell RNASeq (coming up)

  

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Bioinformatics Services (coming up soon)

• Pacbio Revio
  
  • HiFi sequencing alignments (genome reference needs to be provided)
  • Isoseq and single cell Isoseq analysis
  • Variant Calling
  • methylong: Extract methylation calls from long reads
• RNA-Seq
  
  • rnaseq: Pipeline using STAR, HISAT2, RSEM, or Salmon with gene/isoform counts and quality control.
  • differentialabundance: Differential abundance analysis for feature/ observation matrices
• ATAC-seq
  
  • atacseq: ATAC-seq peak-calling and QC analysis pipeline
• ChIP-Seq
  
  • chipseq: ChIP-seq peak-calling, QC and differential analysis pipeline.
• DNA Methylation
  
  • methylseq: Methylation (Bisulfite-Sequencing) analysis pipeline using Bismark or bwa-meth + MethylDackel
• Single Cell RNAseq:
  
  • scrnaseq: Single-cell RNA-Seq pipeline for barcode-based protocols such as 10x, DropSeq or SmartSeq, offering a variety of aligners and empty-droplet detection

  • scdownstream: A single cell transcriptomics pipeline for QC, integration and making the data presentable.

    

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    Chip Seq.PNG

    

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    SCRNA Seq.PNG

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How to find us

The GBC is located in 4046 LSB. Our operating hours are 8:30am - 5:00pm Monday - Friday (except for BYU holidays)

The GBC is supported by Brigham Young University through the Department of Biology under the direction of Tommy W. Terooatea and managed by Emily Andersen.