In the CPTAC consortium, we characterize tumors with both proteomic and genomic data. We use multi-omics data to reveal new hints at cancer therapies, like using DNA copy number alterations and their trans-effected proteins to create a signature of survival in ovarian cancer(Cell 2016). We are also interested in the function of post-translational modifications and how these intersect with DNA mutations. Finally, we are dedicated to open science and data sharing technologies.
Key Questions
What mutations and proteome state are correlated with a good survival in uterine and endometrial cancer?
How do mutations affect the behavior of post-translational modifications?
Are protein complexes dysregulated in a consistent manner across tumor types?
Machine Learning and Forensics
Bioinformatics can be used to identify a victim, criminal, or unknown sample. A wide variety prosecutorial needs are not met by DNA evidence, and could be solved by proteomic evidence. Here, there exists less of a data and statistical framework for how one measures accuracy and validity, i.e. what would be admissible in a court of law (JPR 2018).
Key Questions
How can we measure and characterize human proteome variability?
What is a statistically confident identification in a legal situation?
Can we distinguish different human tissues at crime scenes?